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Teriparatid Tedavisi Altında Sarkopeni ve Kırılganlık: Tesadüf veya Sonuç
Sarcopenia and Frailty Under Teriparatide Treatment: Coincidence or Consequence
Received Date : 04 May 2021
Accepted Date : 28 Jun 2021
Available Online : 06 Jul 2021
Doi: 10.31609/jpmrs.2021-84236 - Makale Dili: EN
J PMR Sci. 2021;24(3):313-6
ÖZET
Osteoporoz, düşük kemik kütlesi ve kemik dokusunun mikromimarisinin bozulması ile karakterizedir ve kırık riskinin artmasına neden olur. Osteoporoz teşhisi konulan hastalarda, antiosteoporoz tedavisi düzenlenmelidir. Teriparatid, vertebra ve vertebra dışı kırık riskini azaltan anabolik ilaçlardan biridir. Kas güçsüzlüğü yan etki olarak bildirilmesine rağmen bildiğimiz kadarıyla, teriparatid tedavisinin yan etkisi olarak sarkopeniye dikkat çeken bir olgu sunumu yoktur. Sarkopeni, olumsuz sonuçlarla ilişkili olan ve genellikle yaşlı insanlarda görülen bir kas bozukluğudur. Yaşa bağlı kas ve kemik kaybından aynı genetik, mekanik, beslenme ve endokrin faktörler sorumlu olabileceği için, son zamanlarda osteosarkopeni terimi tanımlanmıştır. Burada teriparatid tedavisi sonrası sarkopeni ve kırılganlık tanısı alan bir olguyu sunduk ve teriparatid ile sarkopeni arasındaki olası ilişkiye dikkat çekmeyi amaçladık.
ABSTRACT
Osteoporosis is characterized by low bone mass and micro-architectural deterioration of bone tissue and causes increased fracture risk. In patients diagnosed with osteoporosis, anti-osteoporosis treatment should be arranged. Teriparatide is one of the anabolic drugs that reduces the risk of vertebral and non-vertebral fractures. Although, muscle weakness was reported as an adverse effect, to our best knowledge, there is no case presentation that take attention sarcopenia as an adverse effect of teriparatide treatment. Sarcopenia is a muscle disorder that is related to adverse outcomes and seen in generally older people. Since the same genetic, mechanical, nutritional and endocrine factors may be responsible for the age-related muscle and bone loss, recently, the term of osteosarcopenia has been defined. Herein, we reported a case diagnosed with sarcopenia and frailty after teriparatide treatment and aimed to take attention for the possible relationship between teriparatide and sarcopenia.
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