OLGU SUNUMLARI
Teriparatid Tedavisi Altında Sarkopeni ve Kırılganlık: Tesadüf veya Sonuç
Sarcopenia and Frailty Under Teriparatide Treatment: Coincidence or Consequence
Received Date : 04 May 2021
Accepted Date : 28 Jun 2021
Available Online : 06 Jul 2021
Ayşe Merve ATAa, Murat KARAb, Özgür KARAc, Levent ÖZÇAKARa
aDepartment of Physical and Rehabilitation Medicine, Bursa Dr. Ayten Bozkaya Spastic Children Hospital and Rehabilitation Center, Bursa, TURKEY
bDepartment of Physical and Rehabilitation Medicine, Hacettepe University Faculty of Medicine, Ankara, TURKEY
cDepartment of Geriatrics, Yıldırım Beyazıt University Yenimahalle Training and Research Hospital, Ankara, TURKEY
Doi: 10.31609/jpmrs.2021-84236 - Makale Dili: EN
J PMR Sci. 2021;24(3):313-6
ÖZET
Osteoporoz, düşük kemik kütlesi ve kemik dokusunun mikromimarisinin
bozulması ile karakterizedir ve kırık riskinin artmasına
neden olur. Osteoporoz teşhisi konulan hastalarda, antiosteoporoz tedavisi
düzenlenmelidir. Teriparatid, vertebra ve vertebra dışı kırık riskini
azaltan anabolik ilaçlardan biridir. Kas güçsüzlüğü yan etki olarak
bildirilmesine rağmen bildiğimiz kadarıyla, teriparatid tedavisinin yan
etkisi olarak sarkopeniye dikkat çeken bir olgu sunumu yoktur. Sarkopeni,
olumsuz sonuçlarla ilişkili olan ve genellikle yaşlı insanlarda görülen
bir kas bozukluğudur. Yaşa bağlı kas ve kemik kaybından aynı
genetik, mekanik, beslenme ve endokrin faktörler sorumlu olabileceği
için, son zamanlarda osteosarkopeni terimi tanımlanmıştır. Burada teriparatid
tedavisi sonrası sarkopeni ve kırılganlık tanısı alan bir olguyu
sunduk ve teriparatid ile sarkopeni arasındaki olası ilişkiye dikkat çekmeyi
amaçladık.
Anahtar Kelimeler: Osteosarkopeni; teriparatid; kemik; kas; ultrason
ABSTRACT
Osteoporosis is characterized by low bone mass and
micro-architectural deterioration of bone tissue and causes increased
fracture risk. In patients diagnosed with osteoporosis, anti-osteoporosis
treatment should be arranged. Teriparatide is one of the anabolic
drugs that reduces the risk of vertebral and non-vertebral fractures. Although,
muscle weakness was reported as an adverse effect, to our best
knowledge, there is no case presentation that take attention sarcopenia
as an adverse effect of teriparatide treatment. Sarcopenia is a muscle
disorder that is related to adverse outcomes and seen in generally older
people. Since the same genetic, mechanical, nutritional and endocrine
factors may be responsible for the age-related muscle and bone loss,
recently, the term of osteosarcopenia has been defined. Herein, we reported
a case diagnosed with sarcopenia and frailty after teriparatide
treatment and aimed to take attention for the possible relationship between
teriparatide and sarcopenia.
Keywords: Osteosarcopenia; teriparatide; bone; muscle; ultrasound
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