ORIJINAL ARAŞTIRMA
Sjögren Sendromu olan Hastalarda Fibromiyalji Sıklığı ve Hastalık Şiddetine Etkisi
Frequency of Fibromyalgia in Patients with Sjögren’s Syndrome and its Effect on Disease Severity
Received Date : 27 Dec 2020
Accepted Date : 16 Aug 2021
Available Online : 12 Apr 2021
Burcu METİN ÖKMENa, Koray AYARb, Lale ALTANc, Özgür YEŞİLÖZa
aDepartment of Physical Medicine and Rehabilitation, University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital,
Bursa, TURKEY
bDepartment of Rheumatology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, TURKEY
cDepartment of Physical Medicine and Rehabilitation, Bursa Uludağ University Faculty of Medicine, Bursa, TURKEY
Doi: 10.31609/jpmrs.2020-80845 - Makale Dili: EN
J PMR Sci. 2021;24(3):231-7
ÖZET
Amaç: Bu çalışma, primer Sjögren sendromu (pSS) olan hastalarda
fibromiyalji sendromu (FMS) sıklığını ve FMS ile hastalık aktivitesini gösteren
parametreler arasındaki ilişkiyi belirlemeyi amaçlamaktadır. Gereç ve
Yöntemler: Bu prospektif, kesitsel çalışmaya, 18-75 yaşları arasında Sjögren
sendromu tanısı almış 50 hasta dâhil edildi. Hastaların demografik özellikleri,
düzenli kullandıkları ilaçlar ve muayeneye geldikleri zaman ölçülen
rutin eritrosit sedimantasyon hızı (ESH) değerleri kaydedildi. Tüm hastalara
2013 Amerikan Romatoloji Koleji [American College of Rheumatology
(ACR)] fibromiyalji kriterleri uygulandı ve Sjögren sendromu hastalığı
aktivitesini değerlendirmek için EULAR Sjögren's Sendromu Hasta Bildirim
İndeksi [EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI)]
uygulandı. 2013 ACR kriterlerine göre FMS tanısı konan hastaların
sıklığı hesaplandı. Hastalar FMS olup olmamasına göre 2 gruba ayrıldı.
Gruplar arasında ESSPRI skorları ve ESH istatistiksel olarak analiz edildi.
Bulgular: pSS’li 50 hastanın %42’sinde FMS tespit edildi. Yorgunluk ve
ağrı parametreleri skorları ve ortalama ESSPRI skoru FMS’li hastalarda anlamlı
olarak yüksekti (p<0,05), kuruluk parametresinde anlamlı bir fark bulunmadı
(p>0,05). Ortalama ESH, FMS’li hastalarda anlamlı olarak daha
yüksekti (p<0,05). Sonuç: Bu çalışmanın sonuçları, pSS’li hastalarda
FMS’nin yüksek oranda görüldüğünü ve bunun hastalık aktivitesini olumsuz
etkileyebileceğini göstermektedir. Klinisyenlerin FMS ile pSS arasındaki
olası ilişkinin ve 2 durumu aynı anda tedavi etme ihtiyacının farkında
olmaları gerektiğini düşünmekteyiz.
Anahtar Kelimeler: Primer Sjögren sendromu; fibromiyalji; EULAR Sjögren's Sendromu Hasta Bildirim İndeksi; hastalık aktivitesi; eritrosit sedimentasyon hızı
ABSTRACT
Objective: This study aims to determine the frequency of
fibromyalgia syndrome (FMS) among patients with primary Sjögren’s
syndrome (pSS), and the relationship between FMS and the parameters
indicating disease activity. Material and Methods: Fifty patients with
a diagnosis of Sjögren's syndrome, aged 18-75, were included in this
prospective, cross-sectional study. The demographic characteristics of
the patients, regular medications and the routine erythrocyte sedimentation
rate (ESR) values measured when they came for examination were
recorded. The 2013 American College of Rheumatology (ACR) fibromyalgia
criteria were applied to all patients and the EULAR Sjögren's
Syndrome Patient Reported Index (ESSPRI) was applied to evaluate Sjögren's
syndrome disease activity. The frequency of patients diagnosed
with FMS according to the 2013 ACR criteria was calculated. The patients
were divided into 2 groups according to whether they had FMS or
not. The ESSPRI scores and ESR were statistically analyzed between
the groups. Results: FMS was detected in 42% of 50 patients with pSS.
The mean ESSPRI score and scores for the fatigue and pain parameters
were significantly higher in patients with FMS (p<0.05), while no significant
difference was found in the dryness parameter (p>0.05). The
mean ESR was significantly higher in patients with FMS (p<0.05). Conclusion:
The results of this study show that FMS is seen at a high rate
in patients with pSS and this may negatively affect the disease activity.
We think that clinicians should be aware of the possible relationship between
FMS and pSS and the need to treat both conditions simultaneously.
Keywords: Primary Sjögren’s syndrome; fibromyalgia; EULAR Sjögren's Syndrome Patient Reported Index; disease activity; erythrocyte sedimentation rate
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