ORIJINAL ARAŞTIRMA
Sağlıklı Kontrollere Kıyasla Romatoid Artrit ve Ankilozan Spondylitis Hastalarında Kardiyovasküler Hastalık Risk Faktörleri ve Metabolik Sendrom Sıklığı: Kesitsel Bir Çalışma
Cardiovascular Disease Risk Factors and the Frequency of Metabolic Syndrome in Patients with Rheumatoid Arthritis and Ankylosing Compare with Healthy Controls: A Cross-Sectional Study
Received Date : 01 May 2021
Accepted Date : 24 Jan 2022
Available Online : 31 Jan 2022
Öznur KUTLUKa, Cahit KAÇARa
aDepartment of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University Faculty of Medicine, Antalya, TURKIYE
Doi: 10.31609/jpmrs.2021-84189 - Makale Dili: EN
J PMR Sci. 2022;25(2):141-9
ÖZET
Amaç: Bu çalışmanın amacı, ankilozan spondilit (AS) ve romatoid
artritli (RA) hastalarda kardiyovasküler risk faktörleri ve metabolik sendrom
(MetS) varlığını sağlıklı kontrollerle karşılaştırmak ve hastalık aktivite skorları
ile arasındaki ilişkiyi belirlemektir. Gereç ve Yöntemler: Bu kesitsel çalışmada,
RA tanısı almış 52 hasta, AS tanısı almış 49 hasta ve 49 sağlıklı
kontrol çalışmaya alındı. Her hastanın açlık glukoz seviyeleri, lipid profili
ve inflamatuar belirteçlerine bakıldı. Framingham risk skoru (FRS) ve belboy
oranı [waist-to-height ratio (WHtR)] hesaplandı, MetS varlığı saptandı.
Bulgular: MetS prevalansı, AS ve RA hastalarında kontrollere göre daha
yüksekti. Hem RA hem de AS hasta gruplarında kontrol grubuna göre anlamlı
olarak daha yüksek WHtR değerleri bulundu; ayrıca WHtR değerleri
MetS’li hastalarda, MetS olmayan hasta grubuna göre anlamlı olarak daha
yüksek bulundu. MetS’li RA ve AS hasta gruplarında FRS’ler, MetS’li kontrol
grubuna göre istatistiksel olarak daha yüksekti (p=0,019). FRS’ler, hastalık
aktivitesi yüksek olan RA hastalarında, hastalık aktivitesi düşük RA
hastalarına göre anlamlı olarak daha yüksekti (p=0,030). Sonuç: MetS, RA
ve AS hastalarında kontrollere göre daha yaygındı. Kardiyovasküler risk
skorları, MetS hastalarında MetS olmayan has- talara göre daha güçlüydü ve
ayrıca hastalık aktivitesi yüksek olan RA hastalarında kardiyovasküler risk,
düşük hastalık aktivitesi olan RA hastalarına göre daha yüksekti.
Anahtar Kelimeler: Romatoid artrit; ankilozan spondilit; kardiyovasküler risk; metabolik sendrom
ABSTRACT
Objective: The purpose of this study to determine the presence
of cardiovascular risk factors and metabolic syndrome (MetS) according
to healthy controls in patients with ankylosing spondylitis (AS) and
rheumatoid arthritis (RA) and to determine the relationship between the disease
activity scores of these rheumatic diseases and the risk of cardiovascular
disease. Material and Methods: In this cross-sectional study, 52
patients with a diagnosis of RA, 49 patients with a diagnosis of AS, and 49
healthy controls were included in the study. Glucose levels, lipid profile,
and inflammatory markers were registered. The Framingham risk score
(FRS) and waist-to-height ratio (WHtR) were calculated,the presence of
MetS was detected. Results: The prevalence of MetS was higher among patients
with AS and RA than in the controls. We found significantly higher
WHtR values in both the RA and AS groups compared with the control
group. Also, WHtR values were significantly higher in patients with MetS
than in the non-MetS group. FRS values in the RA and AS groups with MetS
were statistically higher than in the control group with MetS (p=0.019). FRS
values were significantly higher in patients with RA with high disease activity
scores than in patients with RA with low disease activity (p=0.030).
Conclusion: MetS was more common in patients with RA and AS than in
controls. Predictors of cardiovascular risk were stronger in patients with
MetS than in patients without MetS and were stronger in patients with RA
with high disease activity scores than in those with low disease activity.
Keywords: Rheumatoid arthritis; ankylosing spondylitis; cardiovascular risk; metabolic syndrome
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