ORIJINAL ARAŞTIRMA
Psöriyazis ve Psöriyatik Artritte Ağrının Nöropatik Bileşeni: Kesitsel Bir Çalışma
A Cross-Sectional Assessment of Neuropathic Pain in Patients with Psoriasis and Psoriatic Arthritis
Received Date : 15 Sep 2019
Accepted Date : 05 Nov 2019
Available Online : 19 Dec 2019
Tuba GÜLERa, Yeşim GARİP ÇİMENa, Nurşad ASLANb, Fulya DÖRTBAŞc
aAnkara Numune Training and Research Hospital, Clinic of Physical Medicine and Rehabilitation, Ankara, TURKEY
bKocaeli Derince Training and Research Hospital, Clinic of Dermatology, Kocaeli, TURKEY
cEmsey Hospital, Clinic of Rheumatology, İstanbul, TURKEY
Doi: 10.31609/jpmrs.2019-70757 - Makale Dili: EN
J PMR Sci. 2020;23(1):1-6
ÖZET
Amaç: Psöriyazis (Ps) ve psöriyatik artrit (PsA) olan birçok
hastada, ciltte rahatsızlık, yanma, acı, tahriş ve aşırı duyarlılık gibi çeşitli
duyusal cilt semptomları gelişebilir ve nöropatik ağrı bu duyusal
cilt semptomlarının bir bileşeni olabilir. Bu çalışma, Ps ve PsA hastalarında
nöropatik ağrı varlığını değerlendirmeyi ve hastalık şiddeti ile ağrı
skorları arasındaki ilişkiyi araştırmayı amaçlamaktadır. Gereç ve Yöntemler:
Çalışmaya 79 Ps, 21 PsA hastası ve 45 sağlıklı kontrol alındı.
Nöropatik ağrı PainDETECT anketi [PainDETECT Questionnaire
(PDQ)] ile, ağrı şiddeti Görsel Analog Skala [Visual Analog Scale (VAS)]
ile değerlendirildi. Hastalık şiddeti ve yaşam kalitesini değerlendirmek
için sırasıyla Psöriyazis Alan Ciddiyeti İndeksi (PASI) ,Dermatoloji
Yaşam Kalitesi İndeksi (DLQI) ve Nottingham Sağlık Profili (Nottingham
Health Profile (NHP) kullanıldı. Bulgular: PsA’lı hastalarda,
Ps’li hastalar ve sağlıklı kontrollerle karşılaştırıldığında anlamlı olarak
daha yüksek “muhtemel nöropatik ağrı” değerleri izlendi (sırasıyla;
%19, %3,8 ve %6,7). Ortalama PDQ skorları Ps ve PsA gruplarında
kontrol grubuna göre daha yüksek bulundu. PsA grubu, Ps grubuna göre
anlamlı derecede kötü ağrı, fiziksel aktivite ve yorgunluk skorlarına sahipti.
Sonuç: Bulgularımız nöropatik ağrının PsA hastalarında ortaya
çıkan duyusal semptomların bir bileşeni olabileceğini düşündürmektedir.
Bununla birlikte, psöriyazis hastalık şiddeti ve nöropatik
ağrı arasında bir ilişki bulunamadı.
Anahtar Kelimeler: Nöropatik ağrı; psöriyazis; psöriyatik artrit
ABSTRACT
Objective: Many patients with psoriasis (Ps) and psoriatic
arthritis (PsA) develop a variety of sensory skin symptoms as
discomfort, burning, stinging, irritation and hypersensitivity. We hypothesize
that neuropathic pain (NP) is a component of these sensory
skin symptoms. This study aims to assess the prevalence of NP
in patients with Ps and PsA and to investigate the association between
disease severity and pain scores. Material and Methods: We
conducted a cross-sectional study on 79 Ps patients, 21 PsA patients,
and 45 healthy individuals. NP was assessed by the PainDETECT
Questionnaire (PDQ). Pain intensity was scored on Visual Analogue
Scales (VAS). We used the Psoriasis Area Severity Index (PASI) and
the Dermatology Life Quality Index (DLQI) and Nottingham Health
Profile (NHP) to assess the disease severity and quality of life, respectively.
Results: PsA patients had significantly more “likely neuropathic
pain” compared with Ps patients and healthy controls (19%
vs. 3.8% and 6.7%). The mean PDQ scores were higher in the Ps and
PsA groups than the control group. PsA group had significantly
worse scores of pain, physical activity, and fatigue compared with
the Ps group. Conclusion: Our findings suggest that neuropathic pain
may be a component of the sensory symptoms manifested in PsA patients.
However, no association was found between disease severity
and neuropathic pain.
Keywords: Neuropathic pain; psoriasis; psoriatic arthritis
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