ORIJINAL ARAŞTIRMA
Metabolik Sendromlu Hastalarda Vitamin D Eksikliğinin Değerlendirilmesi ve Anksiyete-Depresyon Üzerine Etkisinin İncelenmesi
Evaluation of Vitamin D Deficiency in Patients with Metabolic Syndrome and its Effect on Anxiety-Depression
Received Date : 28 Jun 2020
Accepted Date : 14 Sep 2020
Available Online : 18 Jan 2021
Dilek EKER BÜYÜKŞİRECİa, Belgin KARAOĞLANb
aClinic of Physical Medicine and Rehabilitation, Hitit University Erol Olçok Training and Research Hospital, Çorum, TURKEY
bDepartment of Physical Medicine and Rehabilitation, Gazi University Faculty of Medicine, Ankara, TURKEY
Doi: 10.31609/jpmrs.2020-77742 - Makale Dili: EN
J PMR Sci. 2021;24(1):23-6
ÖZET
Amaç: Bu çalışmada, metabolik sendromlu hastalarda vitamin D
eksikliğinin değerlendirilmesi ve anksiyete-depresyon üzerine etkisinin
incelenmesi amaçlandı. Gereç ve Yöntemler: Uluslararası Diyabet Federasyonu
2005 kriterlerine göre metabolik sendromu olan 35 katılımcı,
metabolik sendromu grubunda ve metabolik sendromu olmayan 36 katılımcı,
kontrol grubunda olmak üzere toplam 71 katılımcı çalışmaya dâhil
edildi. Romatolojik hastalığı, ortopedik cerrahi öyküsü, fibromiyaljisi
olan, anksiyete-depresyon ve/veya herhangi bir psikiyatrik hastalık nedeniyle
ilaç tedavisi altındaki katılımcılar çalışmadan dışlandı. Çalışma, retrospektif
olarak planlandı. Katılımcıların demografik özellikleri, bel
çevresi ve kalça çevresi ölçümü kayıtları incelendi. Tüm katılımcıların
Hastane Anksiyete-Depresyon (HAD) ölçeği ve HAD ölçeği uygulandığı
tarihteki kan trigliserid, HDL kolesterol, açlık glukozu, vitamin D düzeyleri,
sistolik ve diyastolik kan basınçları retrospektif olarak kaydedildi.
Bulgular: İki grup arasında cinsiyet, yaş, boy, kilo, beden kitle indeksi
ve kalça çevresi ölçümü açısından anlamlı fark yoktu. Bel çevresi ölçümü
metabolik sendrom grubunda, kontrol grubuna göre anlamlı olarak fazla
idi (p=0,031). Trigliserid, açlık kan glukozu düzeyi, sistolik ve diyastolik
kan basıncı metabolik sendrom grubunda kontrol grubuna göre anlamlı
derecede yüksek saptandı. İki grup arasında vitamin D düzeyi açısından
anlamlı fark saptanmadı. Anksiyete skoru 2 grup arasında benzer saptanırken,
depresyon skoru metabolik sendrom grubunda kontrol grubuna
göre anlamlı derece yüksek saptandı (sırasıyla; p=0,917, p=0,008). Metabolik
sendromu olan grupta vitamin D düzeyi ile bel çevresi, kalça çevresi,
trigliserid düzeyi, HDL kolesterol düzeyi, açlık kan şekeri, anksiyete ve
depresyon skorları arasında korelasyon saptanmadı. Sonuç: Metabolik
sendromu olanlarda, vitamin D eksikliğinden bağımsız olarak depresyon
düzeyinde artış olduğu saptandı. Metabolik sendromu olanlarda, depresyon
ve anksiyete ile vitamin D düzeyleri arasında ilişki olmadığı düşünüldü.
Anahtar Kelimeler: Vitamin D; metabolik sendrom; anksiyete-depresyon
ABSTRACT
Objective: To evaluate vitamin D deficiency in patients with
metabolic syndrome and to examine its effect on anxiety-depression. Material
and Methods: Seventy one participants diagnosed with and without
metabolic syndrome according to the International Diabetes Federation 2005
criteria were included into the study (35 participants in metabolic syndrome
group, 36 participants in control group). Participants with rheumatological
disease, fibromyalgia, anxiety-depression, history of orthopedic surgery
and/or medication for any psychiatric illness were excluded from the study.
The study was planned retrospectively. Demographic characteristics, waist
and hip circumference measurement were examined. Blood triglyceride,
HDL cholesterol, fasting plasma glucose, vitamin D levels, systolic and diastolic
blood pressures and hospital anxiety-depression (HAD) scale were
recorded retrospectively at the date when the HAD scale were applied. Results:
Gender, age, height, weight, body mass index and hip circumference
measurement were similar in both groups. Waist circumference measurement
was significantly higher in the metabolic syndrome group compared to
the control group (p=0.031). Triglyceride, fasting plasma glucose level,
systolic and diastolic blood pressure were found to be significantly higher
in the metabolic syndrome group compared to the control group. There was
no significant difference in vitamin D level between two groups. While the
anxiety score was found to be similar between two groups, the depression
score was significantly higher in the metabolic syndrome group compared
to the control group (respectively; p=0.917, p=0.008). There was no correlation
between blood vitamin D level and waist circumference, hip circumference
measurements, blood triglyceride, HDL cholesterol, fasting plasma
glucose levels, anxiety and depression scores in the metabolic syndrome
group. Conclusion: Independent of vitamin D deficiency, an increase in the
level of depression was detected in participants with metabolic syndrome.
It was thought that there was no relationship between depression, anxiety
and vitamin D levels in patients with metabolic syndrome.
Keywords: Vitamin D deficiency; metabolic syndrome; anxiety-depression
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