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ORIJINAL ARAŞTIRMA

COVID-19 Enfeksiyonu Sonrası Nöropatik Ağrı
Neuropathic Pain After COVID-19 Infection
Received Date : 10 Aug 2023
Accepted Date : 29 Apr 2024
Available Online : 02 May 2024
Doi: 10.31609/jpmrs.2023-99040 - Makale Dili: EN
Turkiye Klinikleri Journal of Physical Medicine and Rehabilitation Sciences. 2024;27(2):96-104
ÖZET
Amaç: Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonunda ağrı sıklıkla solunumsal semptomlara hastalığın her sürecinde eşlik etmektedir. Biz de çalışmamızda, geçirilmiş COVID-19 enfeksiyonu sonrası nöropatik ağrı sıklığını araştırmayı hedefledik. Gereç ve Yöntemler: Çalışmaya ağrı şikâyeti ile başvuran hastalardan COVID-19 geçiren 250 hasta dâhil edildi. Hastalar subakut-uzamış COVID-19 (akut hastalık başlangıcından sonraki 4-12. haftalar arasındaki klinik tablo) Grup 1 ve kronik post-COVID- 19 sendromu (akut hastalık başlangıcından sonraki 12. haftadan uzun süren ve alternatif tanılarla açıklanamayan klinik tablo) Grup 2 olarak incelenmiştir. Hastaların görsel analog skala, depresyon anksiyete skalası, Pain detect nöropatik ağrı anketi de değerlendirildi. Bulgular: 143 (%57,2) kadın, 107 (%42,8) erkek hastanın katıldığı çalışmamızda, Grup 1 hasta sayımız 130 (%52), Grup 2 hasta sayımız ise 120 (%48) idi. Nöropatik ağrısı olan hasta sayımız 32 (%12,8) idi. Nöropatik ağrısı olan hastalarımızın %68,8’i (n=22) Grup 2’de idi. Nöropatik ağrı durumuna etki eden risk faktörlerinin incelenmesi ile Grup 1’de nöropatik ağrı riski 0,371 kat daha az iken (p: 0,014), hastane yatışı olanlarda 4,28 (p<0,001), yoğun bakım ihtiyacı olanlarda 16,53 (p<0,001), pulmoner tutulumu olanlarda 5,23 kat (p<0,001) nöropatik ağrı riskinde artış saptanmıştır. Sonuç: Geçirilmiş COVID-19 enfeksiyonu sonrası ağrı yönetiminde nöropatik ağrının varlığı, özellikle hastane yatışı, yoğun bakım ihtiyacı ve pulmoner tutulumu olanlarda dikkatle irdelenmelidir.
ABSTRACT
Objective: Pain often accompanies respiratory symptoms in coronavirus disease-2019 (COVID-19) during all stages of the disease). The present study aimed to investigate the presence of neuropathic pain and other clinical symptoms in patients with COVID-19. Material and Methods: A total of 250 patients who had recovered from COVID-19 and presented with the pain symptom after the disease were included in the study. The patients were classified into the following two groups: Group 1 with subacute-prolonged COVID-19 (clinical presentation for 4-12 weeks after onset of acute disease) and Group 2 with chronic-post COVID-19 syndrome (clinical presentation lasting for >12 weeks after onset of acute disease and could not be explained by any of the alternative diagnoses). PainDETECT Questionnaire, visual analog scale, and depression anxiety scale were used for the evaluations. Results: The patients included in the study comprised 143 (57.2%) females and 107 (42.8%) males. Among all patients, 130 patients were classified into Group 1 (52%) while 120 patients were classified into Group 2 (48%). Neuropathic pain was experienced by 32 (12.8%) patients, and 68.8% (n=22) of the patients with neuropathic pain were classified into Group 2. Neuropathic pain was 0.371 times lower in Group 1 patients (p: 0.014), while it was 4.28 times higher in patients who had been hospitalized (p<0.001), 16.53 times higher in patients who had been admitted to the intensive care unit (p<0.001), and 5.23 times higher in patients who had experienced pulmonary involvement (p<0.001). Conclusion: After patients recover from COVID-19, they should be carefully evaluated for the presence of neuropathic pain and provided pain management, particularly those who were hospitalized, admitted to the intensive care unit, and had experienced pulmonary involvement during the disease.
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