ORIJINAL ARAŞTIRMA
COVID-19 Enfeksiyonu Sonrası Nöropatik Ağrı
Neuropathic Pain After COVID-19 Infection
Received Date : 10 Aug 2023
Accepted Date : 29 Apr 2024
Available Online : 02 May 2024
Türkan TUNCERa, Vuslat ACARb
aElazığ Fethi Sekin City Hospital, Clinic of Physical Medicine and Rehabilitation, Elazığ, Türkiye
bElazığ Fethi Sekin City Hospital, Clinic of Neurology, Elazığ, Türkiye
Doi: 10.31609/jpmrs.2023-99040 - Makale Dili: EN
Turkiye Klinikleri Journal of Physical Medicine and Rehabilitation Sciences. 2024;27(2):96-104
ÖZET
Amaç: Koronavirüs hastalığı-2019 [coronavirus disease-2019
(COVID-19)] enfeksiyonunda ağrı sıklıkla solunumsal semptomlara
hastalığın her sürecinde eşlik etmektedir. Biz de çalışmamızda, geçirilmiş
COVID-19 enfeksiyonu sonrası nöropatik ağrı sıklığını araştırmayı
hedefledik. Gereç ve Yöntemler: Çalışmaya ağrı şikâyeti ile
başvuran hastalardan COVID-19 geçiren 250 hasta dâhil edildi. Hastalar
subakut-uzamış COVID-19 (akut hastalık başlangıcından sonraki
4-12. haftalar arasındaki klinik tablo) Grup 1 ve kronik post-COVID-
19 sendromu (akut hastalık başlangıcından sonraki 12. haftadan uzun
süren ve alternatif tanılarla açıklanamayan klinik tablo) Grup 2 olarak
incelenmiştir. Hastaların görsel analog skala, depresyon anksiyete skalası,
Pain detect nöropatik ağrı anketi de değerlendirildi. Bulgular: 143
(%57,2) kadın, 107 (%42,8) erkek hastanın katıldığı çalışmamızda,
Grup 1 hasta sayımız 130 (%52), Grup 2 hasta sayımız ise 120 (%48)
idi. Nöropatik ağrısı olan hasta sayımız 32 (%12,8) idi. Nöropatik ağrısı
olan hastalarımızın %68,8’i (n=22) Grup 2’de idi. Nöropatik ağrı
durumuna etki eden risk faktörlerinin incelenmesi ile Grup 1’de nöropatik
ağrı riski 0,371 kat daha az iken (p: 0,014), hastane yatışı olanlarda
4,28 (p<0,001), yoğun bakım ihtiyacı olanlarda 16,53 (p<0,001),
pulmoner tutulumu olanlarda 5,23 kat (p<0,001) nöropatik ağrı riskinde
artış saptanmıştır. Sonuç: Geçirilmiş COVID-19 enfeksiyonu sonrası
ağrı yönetiminde nöropatik ağrının varlığı, özellikle hastane yatışı,
yoğun bakım ihtiyacı ve pulmoner tutulumu olanlarda dikkatle irdelenmelidir.
Anahtar Kelimeler: Koronavirüs hastalığı-2019; kronik COVID-19; nöropatik ağrı; subakut-uzamış COVID-19
ABSTRACT
Objective: Pain often accompanies respiratory symptoms
in coronavirus disease-2019 (COVID-19) during all stages of the
disease). The present study aimed to investigate the presence of neuropathic
pain and other clinical symptoms in patients with COVID-19.
Material and Methods: A total of 250 patients who had recovered
from COVID-19 and presented with the pain symptom after the disease
were included in the study. The patients were classified into the
following two groups: Group 1 with subacute-prolonged COVID-19
(clinical presentation for 4-12 weeks after onset of acute disease) and
Group 2 with chronic-post COVID-19 syndrome (clinical presentation
lasting for >12 weeks after onset of acute disease and could not be explained
by any of the alternative diagnoses). PainDETECT Questionnaire,
visual analog scale, and depression anxiety scale were used for
the evaluations. Results: The patients included in the study comprised
143 (57.2%) females and 107 (42.8%) males. Among all patients, 130
patients were classified into Group 1 (52%) while 120 patients were
classified into Group 2 (48%). Neuropathic pain was experienced by 32
(12.8%) patients, and 68.8% (n=22) of the patients with neuropathic
pain were classified into Group 2. Neuropathic pain was 0.371 times
lower in Group 1 patients (p: 0.014), while it was 4.28 times higher in
patients who had been hospitalized (p<0.001), 16.53 times higher in
patients who had been admitted to the intensive care unit (p<0.001),
and 5.23 times higher in patients who had experienced pulmonary involvement
(p<0.001). Conclusion: After patients recover from
COVID-19, they should be carefully evaluated for the presence of neuropathic
pain and provided pain management, particularly those who
were hospitalized, admitted to the intensive care unit, and had experienced
pulmonary involvement during the disease.
Keywords: Coronavirus disease 2019; chronic COVID-19; neuropathic pain; subacute-prolonged COVID-19
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