ORIJINAL ARAŞTIRMA
COVID-19 Enfeksiyonu Sonrası Avasküler Nekroz
Avascular Necrosis After COVID-19 Infection
Received Date : 14 Aug 2022
Accepted Date : 15 Jan 2023
Available Online : 19 Jan 2023
Türkan TUNCERa
aElazığ Fethi Sekin Şehir Hastanesi, Fiziksel Tıp ve Rehabilitasyon Kliniği, Elazığ, Türkiye
Doi: 10.31609/jpmrs.2022-92916 - Makale Dili: TR
J PMR Sci. 2023;26(2):160-6
ÖZET
Amaç: Koronavirüs hastalığı-2019’un [coronavirus disease-2019
(COVID-19)] kemik komplikasyonlarından avasküler nekroz (AVN) hakkında
çok az güncel bilgi bulunmaktadır. Tedavide hayat kurtarıcı kabul
edilen steroid tedavisine ek olarak kritik hastalık ve virüs kaynaklı artan
koagülasyon AVN gelişimine katkıda bulunabilir. Çalışmamızda 2020-2022
yılları arasında AVN tanısı alan hastaları, geçirilmiş COVID-19 enfeksiyonu
yönünden retrospektif taramayı hedefledik. Gereç ve Yöntemler: Çalışma
2020-2022 tarihlerinde radyolojik olarak (manyetik rezonans
görüntüleme) AVN tanısı alan 41 olgu ile gerçekleştirilmiştir. Hastalar yaş,
cinsiyet, ek hastalık varlığı, COVID-19 geçirip geçirmeme, hastane yatışı,
yoğun bakım gereksinimi, akciğer tutulumu, COVID-19 enfeksiyonu sürecinde
kullanılan ilaçlar, COVID-19 geçirme tarihi ve AVN tanı alma süresi
arasında geçen süre ile değerlendirildi. Bulgular: Olguların %34,1’i (n=14)
kadın, %65,9’u (n=27) erkek idi. Olguların %41,5’i (n=17) COVID-19 hastalığı
geçirmiş, %58,5’i (n=24) ise hastalık geçirmemişti. COVID-19 geçirenlerin
%35,3’ünde hastane yatışı, %9’unda yoğun bakım ihtiyacı,
%41,2’sinde pulmoner tutulum, %35,3’ünde ilaç kullanımı saptanmıştır.
Dokuz (%52,9) hasta COVID-19 enfeksiyonu sonrası AVN tanısı almış ve
bu 2 durum arası geçen ortalama süre ise 4,78±1,92 hafta olarak saptanmıştır.
Tüm hasta grubumuzda COVID-19 geçiren ve geçirmeyenler arasında
incelenen parametrelerde farklılık saptanmamıştır. COVID-19 geçiren
hasta grubunda, AVN tanısını COVID-19 öncesi ve sonrasında alanlar arasında
incelenen parametrelerde, kortikosteroid kullanımı ve akciğer tutulumu
açısından anlamlı farklılık saptanmıştır (p<0,001). Sonuç: COVID-19
enfeksiyonu sonrası AVN gelişimi tahmin edilenden daha kısa sürede gelişebilir.
Özellikle pulmoner tutulumu olan ve kortikosteroid kullanan hastalarda
AVN ayırıcı tanıda akılda tutmalıdır.
Anahtar Kelimeler: Avasküler kemik nekrozu; COVID-19 enfeksiyonu; kortikosteroid
ABSTRACT
Objective: There is very little current information about avasculer
necrosis (AVN), one of the bone complications of coronavirus disease-
2019 (COVID-19). In addition to steroid therapy, which is considered
life-saving in treatment, it may contribute to the development of AVN in
critical illness and virus-induced coagulopathy. In our study, we aimed to
retrospectively screen patients diagnosed with AVN between 2020 and 2022
in terms of previous COVID-19 infection. Material and Methods: The
study was conducted between 2020 and 2022. The study was carried out
with 41 cases diagnosed with AVN evaluated by radiological assesment
(magnetic resonance imaging). the patients were evaluated by age, gender,
presence of additional disease, whether they had COVID-19, hospitalization,
need for intensive care, lung involvement, drugs used during the
COVID infection process, the time elapsed between the date of COVID-19
transmission and the time of diagnosis of AVN. Results: 34.1% (n=14) of
the cases were female, 65.9% (n=27) were male. 41.5% (n=17) of the cases
had COVID-19 disease and 58.5% (n=24) did not have any disease. Hospitalization
in 35.3% of those who had COVID-19, need for intensive care in
9%, pulmonary involvement in 41.2%, and drug use in 35,3% were determined.
9 patients (52.9%) were diagnosed with AVN after COVID-19 infection,
and the mean time between these two conditions was found to be
4.78±1.92 weeks. In our entire patient group, no difference was found in
the parameters examined between those who had COVID 19 and those who
did not. On the other hand, in those who had COVID-19, a significant difference
was found in terms of corticosteroid use and lung involvement in the
parameters examined between those who were diagnosed with AVN before
and after COVID-19 (p<0.001). Conclusion: The development of AVN
after COVID-19 infection may develop in a shorter time than expected.
AVN should be kept in mind in the differential diagnosis, especially in patients
with pulmonary involvement and using corticosteroid.
Keywords: Avascular bone necrosis; COVID-19 infection; corticosteroid
REFERENCES
- Xie L, Liu Y, Fan B, et al. Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge. Respir Res. 2005;6:5. [Crossref] [PubMed] [PMC]
- Beverly MC, Murray DW. Subchondral physiology and vasculo-mechanical factors in load transmission and osteoarthritis. Bone Joint Res. 2021;10:571-3. [Crossref] [PubMed] [PMC]
- Addai D, Zarkos J, Pettit M, et al. Outcomes following surgical management of femoroacetabular impingement: a systematic review and meta-analysis of different surgical techniques. Bone Joint Res. 2021;10:574-90. [Crossref] [PubMed] [PMC]
- Disser NP, De Micheli AJ, Schonk MM, et al. Musculoskeletal consequences of COVID-19. J Bone Joint Surg Am. 2020;102:1197-204. [Crossref] [PubMed] [PMC]
- Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506. Erratum in: Lancet. 2020. [Crossref] [PubMed] [PMC]
- Clinical management of severe acute respiratory infection when Novel coronavirus (2019-nCoV) infection is suspected: Interim Guidance. WHO reference number: WHO/nCoV/Clinical/2020.3
- RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, et al. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021;384:693-704. [Crossref] [PubMed] [PMC]
- Weinstein RS. Glucocorticoid-induced osteonecrosis. Endocrine. 2012;41:183-90. [Crossref] [PubMed] [PMC]
- Mont MA, Pivec R, Banerjee S, et al. High-dose corticosteroid use and risk of hip osteonecrosis: meta-analysis and systematic literature review. J Arthroplasty. 2015;30:1506-12.e5. [Crossref] [PubMed] [PMC]
- Griffith JF. Musculoskeletal complications of severe acute respiratory syndrome. Semin Musculoskelet Radiol. 2011;15:554-60. [Crossref] [PubMed]
- Lv H, de Vlas SJ, Liu W, et al. Avascular osteonecrosis after treatment of SARS: a 3-year longitudinal study. Trop Med Int Health. 2009;14 Suppl 1:79-84. [Crossref] [PubMed] [PMC]
- Guo KJ, Zhao FC, Guo Y, et al. The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: a retrospective study. Bone Joint J. 2014;96-B:259-62. [Crossref] [PubMed]
- Zhao FC, Guo KJ, Li ZR. Osteonecrosis of the femoral head in SARS patients: seven years later. Eur J Orthop Surg Traumatol. 2013;23:671-7. [Crossref] [PubMed]
- Patel MS, Gutman MJ, Abboud JA. Orthopaedic considerations following COVID-19: lessons from the 2003 SARS outbreak. JBJS Rev. 2020;8:e2000052. [Crossref] [PubMed]
- Helms J, Tacquard C, Severac F, et al; CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis). High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020;46:1089-98. [Crossref] [PubMed] [PMC]
- Heffler E, Madeira LNG, Ferrando M, et al. Inhaled corticosteroids safety and adverse effects in patients with asthma. J Allergy Clin Immunol Pract. 2018;6:776-81. [Crossref] [PubMed]
- Mehta S, Pandey A. Rhino-orbital mucormycosis associated with COVID-19. Cureus. 2020;12:e10726. [Crossref] [PubMed] [PMC]
- Agarwala SR, Vijayvargiya M, Pandey P. Avascular necrosis as a part of 'long COVID-19'. BMJ Case Rep. 2021;14:e242101. [Crossref] [PubMed] [PMC]
- Jones JP. Osteonecrosis. In: Koopman WJ, ed. Arthritis and Allied Conditions: a Textbook of Rheumatology. 14th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2001. p.2143-64.
- Zhang S, Wang C, Shi L, et al. Beware of steroid-induced avascular necrosis of the femoral head in the treatment of COVID-19-experience and lessons from the SARS epidemic. Drug Des Devel Ther. 2021;15:983-95. [Crossref] [PubMed] [PMC]
- Sodhi N, Acuna A, Etcheson J, et al. Management of osteonecrosis of the femoral head. Bone Joint J. 2020;102-B:122-8. [Crossref] [PubMed]
- Yildiz N, Ardic F, Deniz S. Very early onset steroid-induced avascular necrosis of the hip and knee in a patient with idiopathic thrombocytopenic purpura. Intern Med. 2008;47:1989-92. [Crossref] [PubMed]
- Sulewski A, Sieroń D, Szyluk K, et al. Avascular necrosis bone complication after active COVID-19 infection: preliminary results. Medicina (Kaunas). 2021;57:1311. [Crossref] [PubMed] [PMC]