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ORIJINAL ARAŞTIRMA

COVID-19 Enfeksiyonu Sonrası Avasküler Nekroz
Avascular Necrosis After COVID-19 Infection
Received Date : 14 Aug 2022
Accepted Date : 15 Jan 2023
Available Online : 19 Jan 2023
Doi: 10.31609/jpmrs.2022-92916 - Makale Dili: TR
J PMR Sci. 2023;26(2):160-6
ÖZET
Amaç: Koronavirüs hastalığı-2019’un [coronavirus disease-2019 (COVID-19)] kemik komplikasyonlarından avasküler nekroz (AVN) hakkında çok az güncel bilgi bulunmaktadır. Tedavide hayat kurtarıcı kabul edilen steroid tedavisine ek olarak kritik hastalık ve virüs kaynaklı artan koagülasyon AVN gelişimine katkıda bulunabilir. Çalışmamızda 2020-2022 yılları arasında AVN tanısı alan hastaları, geçirilmiş COVID-19 enfeksiyonu yönünden retrospektif taramayı hedefledik. Gereç ve Yöntemler: Çalışma 2020-2022 tarihlerinde radyolojik olarak (manyetik rezonans görüntüleme) AVN tanısı alan 41 olgu ile gerçekleştirilmiştir. Hastalar yaş, cinsiyet, ek hastalık varlığı, COVID-19 geçirip geçirmeme, hastane yatışı, yoğun bakım gereksinimi, akciğer tutulumu, COVID-19 enfeksiyonu sürecinde kullanılan ilaçlar, COVID-19 geçirme tarihi ve AVN tanı alma süresi arasında geçen süre ile değerlendirildi. Bulgular: Olguların %34,1’i (n=14) kadın, %65,9’u (n=27) erkek idi. Olguların %41,5’i (n=17) COVID-19 hastalığı geçirmiş, %58,5’i (n=24) ise hastalık geçirmemişti. COVID-19 geçirenlerin %35,3’ünde hastane yatışı, %9’unda yoğun bakım ihtiyacı, %41,2’sinde pulmoner tutulum, %35,3’ünde ilaç kullanımı saptanmıştır. Dokuz (%52,9) hasta COVID-19 enfeksiyonu sonrası AVN tanısı almış ve bu 2 durum arası geçen ortalama süre ise 4,78±1,92 hafta olarak saptanmıştır. Tüm hasta grubumuzda COVID-19 geçiren ve geçirmeyenler arasında incelenen parametrelerde farklılık saptanmamıştır. COVID-19 geçiren hasta grubunda, AVN tanısını COVID-19 öncesi ve sonrasında alanlar arasında incelenen parametrelerde, kortikosteroid kullanımı ve akciğer tutulumu açısından anlamlı farklılık saptanmıştır (p<0,001). Sonuç: COVID-19 enfeksiyonu sonrası AVN gelişimi tahmin edilenden daha kısa sürede gelişebilir. Özellikle pulmoner tutulumu olan ve kortikosteroid kullanan hastalarda AVN ayırıcı tanıda akılda tutmalıdır.
ABSTRACT
Objective: There is very little current information about avasculer necrosis (AVN), one of the bone complications of coronavirus disease- 2019 (COVID-19). In addition to steroid therapy, which is considered life-saving in treatment, it may contribute to the development of AVN in critical illness and virus-induced coagulopathy. In our study, we aimed to retrospectively screen patients diagnosed with AVN between 2020 and 2022 in terms of previous COVID-19 infection. Material and Methods: The study was conducted between 2020 and 2022. The study was carried out with 41 cases diagnosed with AVN evaluated by radiological assesment (magnetic resonance imaging). the patients were evaluated by age, gender, presence of additional disease, whether they had COVID-19, hospitalization, need for intensive care, lung involvement, drugs used during the COVID infection process, the time elapsed between the date of COVID-19 transmission and the time of diagnosis of AVN. Results: 34.1% (n=14) of the cases were female, 65.9% (n=27) were male. 41.5% (n=17) of the cases had COVID-19 disease and 58.5% (n=24) did not have any disease. Hospitalization in 35.3% of those who had COVID-19, need for intensive care in 9%, pulmonary involvement in 41.2%, and drug use in 35,3% were determined. 9 patients (52.9%) were diagnosed with AVN after COVID-19 infection, and the mean time between these two conditions was found to be 4.78±1.92 weeks. In our entire patient group, no difference was found in the parameters examined between those who had COVID 19 and those who did not. On the other hand, in those who had COVID-19, a significant difference was found in terms of corticosteroid use and lung involvement in the parameters examined between those who were diagnosed with AVN before and after COVID-19 (p<0.001). Conclusion: The development of AVN after COVID-19 infection may develop in a shorter time than expected. AVN should be kept in mind in the differential diagnosis, especially in patients with pulmonary involvement and using corticosteroid.
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