ORIJINAL ARAŞTIRMA
Ailevi Akdeniz Ateşinde Cinsiyetin Depresyon, Anksiyete ve Yaşam Kalitesine Etkisi
The Effect of Gender on Depression, Anxiety, and Quality of Life in Familial Mediterranean Fever
Received Date : 20 Sep 2022
Accepted Date : 25 Jun 2023
Available Online : 07 Jul 2023
Hatice Ecem KONAKa, Ebru ATALARa, Kevser ORHANa
aAnkara Şehir Hastanesi, Romatoloji Kliniği, Ankara, Türkiye
Doi: 10.31609/jpmrs.2022-93296 - Makale Dili: TR
J PMR Sci. 2023;26(3):335-41
ÖZET
Amaç: AAA (Ailevi Akdeniz Ateşi) hastalarında diğer kronik hastalıklarda
olduğu gibi depresyon,anksiyete ve uyku bozukluğu sıklığı artmıştır.
Ancak cinsiyetin depresyon, anksiyete ve yaşam kalitesine olan etkisi
net olarak araştırılmamıştır. Bu çalışmanın amacı; AAA hastalarında cinsiyetin,
hastalık klinik özellikleri ve hastalık aktivitesi ve Hospital Anxiety
and Depression Scale (HADS) ve Nottingham Health Profile (NHP) kullanılarak
anksiyete, depresyon ve yaşam kalitesi parametreleri üzerine etkisini
incelemektir. Gereç ve Yöntemler: Çalışmamıza dahil edilen AAA hastaların
hastalık başlama yaşı, hastalık süresi,1 yıldaki atak sayısı, atak özellikleri,
amiloidoz varlığı, MEFV gen mutasyonu sonucu, AAA için aldıkları
medikal tedaviler ve International Severity Scoring System (ISSF) not
edildi. Hastaların ağrı ve yorgunluk düzeyleri visüel analog skala (VASağrı/
VAS-yorgunluk) ile ölçüldü. HAD-anksiyete ve HAD- depresyon skalası,
AAA hastalarının anksiyete ve depresyon düzeyini ve şiddetini, NHP
ölçeği yaşam kalitesini değerlendirmek için kullanıldı. Bulgular: Hastalar
cinsiyetine göre iki gruba ayrıldığında, yaş ortalaması, VKİ, medeni durumu,
eğitim durumu ve sigara kullanımı açısından aralarında istatistiksel
olarak anlamlı farklılık yoktu (sırasıyla p=0.218, p=0.383, p=0.505, p=0.246
ve p=0.411). Hastaların cinsiyetine göre HAD-depresyon ve HAD-anksiyete
skorları karşılaştırıldığında kadın hastaların erkek hastalara göre depresyon
ve anksiyete skorları istatistiksel olarak anlamlı bulundu (sırasıyla
p=0.01, p=0.04). Kadın AAA hastalarında erkek hastalara göre NHP uyku
ve emosyonel reaksiyon skorları istatistiksel olarak anlamlı ölçüde daha
yüksek bulundu (sırasıyla p=0.027, p=0.033). Sonuç: Çalışmamızda, her
iki cinsiyette benzer hastalık aktivitesi durumunda dahi; kadın AAA hastalarında
erkeklere göre daha çok depresyon, anksiyete, uyku bozukluğu ve
sosyal izolasyon gözlenmiştir (sırasıyla p=0.01, p=0.04, p = 0.027 ve 0.033).
Bu nedenle hastalığın bu açıdan değerlendirilmesi yararlı olacaktır.
Anahtar Kelimeler: Ailevi Akdeniz ateşi; anksiyete; depresyon
ABSTRACT
Objective: The aim of this study is to examine the effect of
gender on the parameters of anxiety, depression and quality of life in FMF
patients using the disease clinical features and disease activity and the Hospital
Anxiety and Depression Scale (HADS) and the Nothingam Health Profile
(NHP). Material and Methods: Age of onset of disease, duration of
disease, number of attacks per year, attack characteristics, presence of amyloidosis,
MEFV gene mutation result and the International Severity Scoring
System (ISSF) were noted. HAD-anxiety and HAD-depression scales were
used to evaluate the level and severity of anxiety and depression and the
NHP scale was used to evaluate quality of life. Results: When the patients
were divided into two groups according to their gender, there was no statistically
significant difference between them in terms of mean age, marital
status, educational status, and smoking (p=0.218, p=0.505, p=0.246, and
p=0.411, respectively). When the HAD-depression and HAD-anxiety scores
of patients were compared by gender, the depression and anxiety scores of
female patients were found to be statistically significant when compared to
male patients (p = 0.01 and p = 0.04, respectively). NHP sleep and emotional
reaction scores were found to be statistically significantly higher in female
patients compared to male patients (p = 0.027 and 0.033, respectively).
Conclusion: In our study, it was revealed that female FMF patients had
more depression, anxiety, sleep disorders, and social isolation than males
(p=0.01, p=0.04, p = 0.027 and 0.033, respectively).
Keywords: Familial Mediterranean fever; anxiety; depression
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